More to follow on this topic, but for now, the JRC have released (2013) a Report of the Endocrine Disrupters Expert Advisory Group on “Thresholds for Endocrine Disrupters and
Related Uncertainties”. Download the report here.
The report succinctly covers:
- legislative background
- relevance of principles of endocrinology to threshold considerations
- low dose effects
- non-monotonic dose responses (NMDRs)
- limitations of experimental approaches, and solutions
- critical windows of exposure
- mixtures
- overall uncertainties
Key references
Slob W., 1999. Thresholds in toxicology and risk assessment. Int. J. Toxicol., 18, 259-268
Slob W., 2007. What is a Practical Threshold?, Toxicol Pathol., 35: 848
MixTox: towards regulatory implementation 