Kortenkamp A, Scholze M, Ermler S. Mind the gap: can we explain declining male reproductive health with known antiandrogens? Reproduction. 2014 Mar 2;147(4):515-27. doi: 10.1530/REP-13-0440. Print 2014. PubMed PMID: 24435164
This paper asks the question: can our current understanding of human exposure to chemicals with anti-androgenic properties explain the observed decline in male reproductive health – for example manifesting as cryptorchidism, hypospadias and testicular germ cell cancer (the ‘testicular dysgenesis syndrome’)?
Kortenkamp et al. conclude that this hypothesis has an ‘explanation gap’ which can only be bridged if either 1) undiscovered high potency AR antagonists are identified or 2) if there are unidentified high exposures to unknown agents of average AR potency.