More to follow on this topic, but for now, the JRC have released (2013) a Report of the Endocrine Disrupters Expert Advisory Group on “Thresholds for Endocrine Disrupters and
Related Uncertainties”. Download the report here. Continue reading
More will follow on this topic shortly, but for now the German Federal Environment Agency (UBA) has produced an interesting report on the uncertainties in the environmental risk assessment of endocrine active substances, or endocrine disrupting chemicals (EDCs).
Toxicology and the evaluation of the safety of chemicals rest on the principle of Paracelsus. This Swiss alchemist, astrologer and doctor enunciated in the XVIth century that « everything is a poison, nothing is without poison, what makes the poison is the dose». From the point of view of regulatory toxicology, this is interpreted as meaning that it is theoretically possible to determine a threshold dose below which there would be no harmful effects.
The blog will soon get some new types of posts for ‘hot topics’ in mixture toxicology, and the regulatory implementation of MixTox. Hot Topic posts will summarise a particular topic, and discussion of existing topics and proposals for new topics are very welcome. A list of hot topics is here, and comments are welcome through the blog or by contacting us.
MixTox: towards regulatory implementation 