HOT TOPICS | Low dose effects and endocrine disrupters

Toxicology and the evaluation of the safety of chemicals rest on the principle of Paracelsus. This Swiss alchemist, astrologer and doctor enunciated in the XVIth century that « everything is a poison, nothing is without poison, what makes the poison is the dose». From the point of view of regulatory toxicology, this is interpreted as meaning that it is theoretically possible to determine a threshold dose below which there would be no harmful effects.

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HOT TOPICS | new type of post on the blog

The blog will soon get some new types of posts for ‘hot topics’ in mixture toxicology, and the regulatory implementation of MixTox. Hot Topic posts will summarise a particular topic, and discussion of existing topics and proposals for new topics are very welcome. A list of hot topics is here, and comments are welcome through the blog or by contacting us.

INTRO | MixTox: towards regulatory implementation (TRI)

This blog accompanies a project at Brunel University that is working on how mixture toxicology concepts, theory and experimental results should be translated into routine use in chemical regulation. The project is funded by a grant from the Oak Foundation to Professor Andreas Kortenkamp, at the Institute for the Environment, Brunel University.

The project will consider different options for regulation of chemical mixtures, identify barriers and obstacles to implementation, and also identify opportunities and solutions to the issue of how best to achieve protection of human and environmental health from the potential adverse effects of multiple chemicals.

Any interested party should feel welcome to get in touch, via this blog or see the contact us page for contact details.