More to follow on this topic, but for now, the JRC have released (2013) a Report of the Endocrine Disrupters Expert Advisory Group on “Thresholds for Endocrine Disrupters and
Related Uncertainties”. Download the report here. Continue reading
More will follow on this topic shortly, but for now the German Federal Environment Agency (UBA) has produced an interesting report on the uncertainties in the environmental risk assessment of endocrine active substances, or endocrine disrupting chemicals (EDCs).
The German Federal Environment Agency (UBA) has published a report on the evaluation of the uncertainties of the environmental risk assessment of endocrine disrupting chemicals (EDCs). Titled “Substances of very high concern under REACH – an evaluation of uncertainties in the environmental risk assessment of endocrine active substances”; the project aimed to “identify the most relevant factors increasing the uncertainty of the environmental risk assessment (ERA) of endocrine active substances as compared to baseline toxicants.” Continue reading
Toxicology and the evaluation of the safety of chemicals rest on the principle of Paracelsus. This Swiss alchemist, astrologer and doctor enunciated in the XVIth century that « everything is a poison, nothing is without poison, what makes the poison is the dose». From the point of view of regulatory toxicology, this is interpreted as meaning that it is theoretically possible to determine a threshold dose below which there would be no harmful effects.
The blog will soon get some new types of posts for ‘hot topics’ in mixture toxicology, and the regulatory implementation of MixTox. Hot Topic posts will summarise a particular topic, and discussion of existing topics and proposals for new topics are very welcome. A list of hot topics is here, and comments are welcome through the blog or by contacting us.
On 11th September 2014, Edinburgh, UK, EFSA will hold the EFSA Scientific Colloquium N°21: Harmonisation of human and ecological risk assessment of combined exposure to multiple chemicals.
Registration for the event has now closed.
The NC3Rs recently arranged a fascinating meeting on the adverse outcome pathway (AOP) concept, and its position in the future of toxicology. AOPs are the subject of ongoing activity at OECD and potentially invaluable tools are becoming available, for example the OECD AOP Wiki (no public access at present) and the effectopedia.